Is clinical neurology really so difficult?

Is clinical neurology really so difficult?

The hypertensive patient with multiple risk factors: is treatment really so difficult?

Multiple risk factors for cardiovascular disease, particularly hypercholesterolemia, are often present in the hypertensive patient. Recent guidelines, ranging from those prepared by the World Health Organization/International Society of Hypertension to those of the three European Societies of Cardiology, Atherosclerosis, and Hypertension, stress the importance of evaluating global risk, based o...

Why is Knowledge Management So Difficult?

The “big idea” with knowledge management is that in a fast-moving and increasingly competitive world, a firm’s only enduring source of advantage is its knowledge – the knowledge of its individual employees, and the knowledge that gets built into its structures and systems. Consulting companies and R&D organisations have known this for years, but increasingly even “old economy” firms in oil, ste...

Why Is Educational Entrepreneurship so Difficult ?

Much of the recent literature on improving education in the United States seeks to promote entrepreneurship as the solution to raising educational quality and equity. But, the historical record documenting substantial and sustained departure from conventional educational practices is scant despite numerous attempts at entrepreneurial innovation. This paper contends that the challenge of entrepr...

Why is ALS so Difficult to Treat?

Amyotrophic lateral sclerosis (ALS) is proving intractable. Difficulties in pre-clinical studies contribute in small measure to this futility, but the chief reason for failure is an inadequate understanding of disease pathogenesis. Many acquired and inherited processes have been advanced as potential causes of ALS but, while they may predispose to disease, it seems increasingly likely that none...